Nguyen, Thi Thanh Binh’s team published research in Tetrahedron in 69 | CAS: 69626-75-1

Tetrahedron published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, COA of Formula: C8H5IO.

Nguyen, Thi Thanh Binh published the artcileSynthesis of (Z) isomers of benzoheterocyclic derivatives of combretastatin A-4: a comparative study of several methods, COA of Formula: C8H5IO, the publication is Tetrahedron (2013), 69(10), 2336-2347, database is CAplus.

Several methods for the preparation of (Z) trimethoxystyrene derivatives I [R = H, X = O, S, N-Boc, NH; R = OMe, NO2, X = S] & II were investigated. After finding that the Wittig reaction led to unsatisfactory results, three different strategies were considered: a Suzuki coupling with a stereodefined monobromoalkene, a combination of hydrosilylation/vinylsilane hydrolysis and a palladium-catalyzed semi-hydrogenation step, using DMF/KOH as the hydrogen source. Our studies led us to prepare a series of diarylacetylene derivatives via a Sonogashira coupling reaction, and also to find out a copper-free basic cyclization leading to benzo[b]thiophenes. The final choice for the synthesis method of I & II strongly depends on the target compound but the semi-hydrogenation, which avoids the use of a toxic tin reducing agent, should be generally preferred.

Tetrahedron published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, COA of Formula: C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem