《Synergistic antibacterial activity of physical-chemical multi-mechanism by TiO2 nanorod arrays for safe biofilm eradication on implant》 was written by Zhang, Xiangyu; Zhang, Guannan; Chai, Maozhou; Yao, Xiaohong; Chen, Weiyi; Chu, Paul K.. Related Products of 5471-63-6This research focused ontitanium dioxide nanorod array antibacterial activity biofilm eradication implant; Anti-biofilm; Light-triggered therapy; Physical insertion; TiO2 nanorod; Titanium implants. The article conveys some information:
Treatment of implant-associated infection is becoming more challenging, especially when bacterial biofilms form on the surface of the implants. Developing multi-mechanism antibacterial methods to combat bacterial biofilm infections by the synergistic effects are superior to those based on single modality due to avoiding the adverse effects arising from the latter. In this work, TiO2 nanorod arrays in combination with irradiation with 808 near-IR (NIR) light are proven to eradicate single specie biofilms by combining photothermal therapy, photodynamic therapy, and phys. killing of bacteria. The TiO2 nanorod arrays possess efficient photothermal conversion ability and produce a small amount of reactive oxygen species (ROS). Physiol., the combined actions of hyperthermia, ROS, and puncturing by nanorods give rise to excellent antibacterial properties on titanium requiring irradiation for only 15 min as demonstrated by our experiments conducted in vitro and in vivo. More importantly, bone biofilm infection is successfully treated efficiently by the synergistic antibacterial effects and at the same time, the TiO2 nanorod arrays improve the new bone formation around implants. In this protocol, besides the biocompatible TiO2 nanorod arrays, an extra photosensitizer is not needed and no other ions would be released. Our findings reveal a rapid bacteria-killing method based on the multiple synergetic antibacterial modalities with high biosafety that can be implemented in vivo and obviate the need for a second operation. The concept and antibacterial system described here have large clin. potential in orthopedic and dental applications. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6Related Products of 5471-63-6)
1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Related Products of 5471-63-6
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem