Organocatalyzed asymmetric dearomative 1,3-dipolar cycloaddition of 2-nitrobenzofurans and N-2,2,2-trifluoroethylisatin ketimines was written by Zhou, Xiao-Jian;Zhao, Jian-Qiang;Lai, Yue-Qin;You, Yong;Wang, Zhen-Hua;Yuan, Wei-Cheng. And the article was included in Chirality in 2022.Application of 33094-66-5 This article mentions the following:
A readily available chiral cyclohexanediamine-derived bifunctional tertiary amine-squaramide catalyst was more effective for the asym. dearomative 1,3-dipolar cycloaddition of 2-nitrobenzofurans and N-2,2,2-trifluoroethylisatin ketimines. A range of structurally diverse spiro-fused polyheterocyclic compounds containing oxindole, pyrrolidine, and hydrobenzofuran motifs were smoothly obtained in excellent results (up to 99% yield, >20:1 dr in all cases and up to 99% ee). This method featureed high efficiency, mild reaction conditions, exquisite asym. induction, wide functional group tolerance, great potential for scale-up synthesis, and attractive product diversification. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Application of 33094-66-5).
2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application of 33094-66-5
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem