Dinuclear Zinc Catalyzed Enantioselective Dearomatization [3+2] Annulation of 2-Nitrobenzofurans and 2-Nitrobenzothiophenes was written by Zhou, Peng;Yi, Yang;Hua, Yuan-Zhao;Jia, Shi-Kun;Wang, Min-Can. And the article was included in Chemistry – A European Journal in 2022.Synthetic Route of C8H5NO3 This article mentions the following:
The application of dinuclear zinc catalysts in a dearomatization reaction was developed. Catalytic asym. dearomatization [3+2] annulations of 2-nitrobenzofurans or 2-nitrobenzothiophenes with CF3-containing N-unprotected isatin-derived azomethine ylides catalyzed by dinuclear zinc catalysts were realized with excellent diastereomer ratios (dr) of >20:1 and enantiomeric excess (ee) of up to 99%. This protocol provided a practical, straightforward access to structurally diverse pyrrolidinyl spirooxindoles containing a 2,3-fused-dihydrobenzofuran (or dihydrobenzothiphene) moiety, and four contiguous stereocenters. Reactions was performed on a gram scale. The absolute configuration of products was confirmed by X-ray single crystal structure anal., and a possible mechanism was proposed. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Synthetic Route of C8H5NO3).
2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Synthetic Route of C8H5NO3
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem