SDS of cas: 87-41-2. Recently I am researching about GENERAL-ACID CATALYSIS; NUCLEOPHILIC-ATTACK; HYDROLYSIS; CONJUGATE; RESONANCE; DESIGN; FIELD; OXIDE, Saw an article supported by the National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [CA223121]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Backer, BS; Choy, CJ; Davis, AL; Browne, ZS; Berkman, CE. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one
We previously described a pH-sensitive phosphoramidate linker scaffold that can be tuned to release amine-containing drugs at various pH values. In these previous studies it was determined that the tunability of this linker was dependent upon the proximity of an acidic group (e.g., carboxylic acid or pyridinium). In this study, we confirmed that the tunability of pH-triggered amine-release was also dependent upon the pK(a) of the proximal acidic group. A series of 2-carboxybenzyl phosphoramidates was prepared in which the pK(a) of the proximal benzoic acid was predictably attenuated by substituents on the benzoate ring consistent with their sigma-values. (C) 2020 Elsevier Ltd. All rights reserved.
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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem