Top Picks: new discover of 496-41-3

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496-41-3, Name is Benzofuran-2-carboxylic acid, belongs to benzofuran compound, is a common compound. Application In Synthesis of Benzofuran-2-carboxylic acidIn an article, once mentioned the new application about 496-41-3.

Tri- and tetrasubstituted imidazoles as p38alpha mitogen-activated protein kinase inhibitors

The synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles as potent p38alpha mitogen-activated protein kinase inhibitors is described. The trisubstituted imidazole series was found to be more potent than the tetrasubstituted imidazole series. Many of these compounds show low-nanomolar activities in the isolated p38alpha MAP kinase inhibition assay. The structure-activity relationships between these two series are different and not comparable.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H1865O – PubChem