Recently I am researching about CATALYZED ASYMMETRIC HYDROGENATION; MOLECULAR-STRUCTURE; COORDINATION; COMPLEXES; PHOSPHORAMIDITE; DERIVATIVES; COMPOUND; LIGANDS; KETONES; ACIDS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21871255, 21532006, 21873096]; Chinese Academy of SciencesChinese Academy of Sciences [XDB17020300, XDB17010200]. Name: Isobenzofuran-1(3H)-one. Published in SCIENCE PRESS in BEIJING ,Authors: Yu, CB; Wang, HD; Song, B; Shen, HQ; Fan, HJ; Zhou, YG. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one
For the metal-catalyzed asymmetric hydrogenation of alpha-substituted ketones, cis reductive products are generally obtained due to steric hindrance of substituents. Herein, an unprecedented trans reductive products were observed in palladium-catalyzed hydrogenative desymmetrization of cyclic and acyclic 1,3-diketones, providing the chiral trans beta-hydroxy ketones with two adjacent stereocenters including one alpha-tertiary or quaternary stereocenter with high enantioselectivity and diastereoselectivity. Mechanistic studies and DFT calculations suggested that the rarely observed diastereoselectivity reversal is ascribed to the charge-charge interaction between the palladium and aromatic ring of the substrate, which could not only result in the reversal of the diastereoselectivity, but also improve the reactivity.
Name: Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem