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Herein we describe the synthesis of novel tricyclic analogues issued from the rigidification of the methoxy group of the benzofuranic analogue of melatonin as MT1 and MT2 ligands Most of the synthesized compounds displayed high binding affinities at MT1 and MT2 receptors subtypes Compound 6b (MT1, Ki = 0.07 nM; MT2, Ki = 0.08 nM) exhibited with the vinyl 6c and allyl 6d the most interesting derivatives of this series Functional activity of these compounds showed full agonist activity with EC50 in the nanomolar range Compounds 6a (EC50 = 0.8 nM and Emax = 98%) and 6b (EC50 = 0.2 nM and Emax = 121%) exhibited good pharmacological profiles

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2237O – PubChem