Application of 13196-11-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 13196-11-7, Name is Benzofuran-6-ol, molecular formula is C8H6O2. In a Article£¬once mentioned of 13196-11-7
Synthetic models related to methoxalen and menthofuran-cytochrome P450 (CYP) 2A6 interactions. Benzofuran and coumarin derivatives as potent and selective inhibitors of CYP2A6
Human microsomal cytochrome P450 (CYP) 2A6 contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. We prepared a series of benzofuran and coumarin derivatives that have inhibitory effects on the activity of human CYP2A6. The reported compounds methoxalen and menthofuran had potent inhibitory effects on the activity of CYP2A6 with IC50 values of 0.47 muM and 1.27 muM, respectively. Synthetic benzofuran (4-methoxybenzofuran: IC50=2.20 muM) and coumarin (5-methoxycoumarin: IC50=0.13 muM and 6-methoxycoumarin: IC50=0.64 muM) derivatives, which have more selective effects than those of methoxalen and menthofuran, exhibited comparable activities against CYP2A6. These compounds can be used as a lead compounds in the design of CYP2A6 inhibitor drugs to reduce smoking and tobacco-related cancers.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 13196-11-7. In my other articles, you can also check out more blogs about 13196-11-7
Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H424O – PubChem