An article Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401 WOS:000593184400001 published article about ACETYLCHOLINESTERASE in [Dai, Yu; Li, Kunlong; She, Jianglian; Liao, Shengrong; Lin, Xiuping; Yang, Bin; Wang, Junfeng; Zhou, Xuefeng; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Peoples R China; [Li, Kunlong; Liao, Shengrong; Lin, Xiuping; Yang, Bin; Wang, Junfeng; Zhou, Xuefeng; Liu, Yonghong] Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China; [Zeng, Yanbo; Wang, Hao; Dai, Haofu] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China; [Tao, Huaming] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China; [Liu, Yonghong] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Shenyang 110016, Peoples R China in 2020, Cited 21. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Recommanded Product: 87-41-2
A pair of novel lipopeptide epimers, sinulariapeptides A (1) and B (2), and a new phthalide glycerol ether (3) were isolated from the marine algal-associated fungus Cochliobolus lunatus SCSIO41401, together with three known chromanone derivates (4-6). The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD), and Mo-2 (OAc)(4)-induced ECD methods. The new compounds 1-3 showed moderate inhibitory activity against acetylcholinesterase (AChE), with IC50 values of 1.3-2.5 mu M, and an in silico molecular docking study was also performed.
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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem