Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: benzofuran. Introducing a new discovery about 3199-61-9, Name is Ethyl benzofuran-2-carboxylate
Development of coumarin?benzofuran hybrids as versatile multitargeted compounds for the treatment of Alzheimer?s Disease
Alzheimer?s disease (AD), the most common cause of dementia, is a neurodegenerative disorder characterized by progressive deterioration of memory and cognition. The evidenced multifactorial nature of AD has been considered the main reason for the absence of cure so far. Therefore, the development of novel hybrids to treat the disease is very much essential. Focusing on this, a novel series of coumarin?benzofuran hybrids have been designed and screened as anti-Alzheimer?s disease agents. The strategy is to obtain an effective mimetic of donepezil, which is acetylcholinesterase inhibitor. Herein, the two main scaffolds namely coumarin and benzofuran are known pharmacophore moieties and we have performed their molecular design, pharmacokinetic descriptor studies for drug-likeliness. Further, in vitro studies such as antioxidant capacity, acetylcholinesterase (AChE) inhibition and amyloid-beta (Abeta) self-aggregation inhibition have also been performed. Most importantly, these studies revealed that the newly synthesized hybrids can be versatile and promising drug-like moieties as efficient anti-AD agents.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: benzofuran, you can also check out more blogs about3199-61-9
Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3022O – PubChem