97148-39-5, Name is Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, molecular formula is C7H10N2O4, Recommanded Product: Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, belongs to benzofurans compound, is a common compound. In a patnet, author is Mokenapelli, Sudhakar, once mentioned the new application about 97148-39-5.
Synthesis, cytotoxicity, and molecular docking of substituted 3-(2-methylbenzofuran-3-yl)-5-(phenoxymethyl)-1,2,4-oxadiazoles
A series of new benzofuran/oxadiazole hybrids (8a-n) was synthesized from 2H-chromene-3-carbonitriles (3a-c) through the multistep synthetic methodology, and these hybrids are known to exhibit anticancer activities. All the compounds were evaluated for their in vitro cytotoxicity against the HCT116 and MIA PaCa2 cell lines. Compounds 6a (IC50: 9.71 +/- 1.9 mu M), 6b (IC50: 7.48 +/- 0.6 mu M), and 6c (IC50: 3.27 +/- 1.1 mu M) displayed a significant cytotoxic activity, whereas compounds 8d and 8e exhibited good activity against both cell lines. The depletion of glycogen synthase kinase-3 beta (GSK3 beta) induces apoptosis through the inhibition of basal NF-kappa B activity in HCT116 colon cancer cells and MIA PaCa2 pancreatic cancer cells. Molecular docking of compounds 6a, 6b, 6c, 8d, and 8e with GSK3 beta demonstrated the best binding affinity, correlating with the biological activity assay. Furthermore, the structure-activity relationship of these novel compounds reveals promising features for their use in anticancer therapy.
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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem