Tag: M.W=200-250

Hou, Zhen-Lin published the artcileSilver-promoted cross-coupling of substituted allyl(trimethyl)silanes with aryl iodides by palladium catalysis, Synthetic Route of 69626-75-1, the publication is Tetrahedron Letters (2018), 59(52), 4557-4561, database is CAplus.

A ligand-free Pd-catalyzed cross-coupling of substituted allyl(trimethyl)silanes with aryl iodides enabled by silver salts was developed [e.g., trimethyl(2-phenylallyl)silane + Me 4-iodobenzoate → Me 4-(2-phenylallyl)benzoate (79%) in presence of Pd(OAc)₂ and Ag₂CO₃ in DCE]. This reaction delivered allylic arenes chemoselectively and regioselectively. The study suggested that the reaction might proceed through oxidative addition of ArI to Pd(0) followed by halide abstraction to give an electrophilic complex ArPdX, which further reacted with allyl(trimethyl)silanes via electrophilic addition/desilylation/reductive elimination to afford the allyl-aryl coupling products.

Tetrahedron Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Synthetic Route of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Lin, Bijin published the artcileGold-Catalyzed Desymmetric Lactonization of Alkynylmalonic Acids Enabled by Chiral Bifunctional P,N ligands, Category: benzofurans, the publication is Angewandte Chemie, International Edition (2022), 61(23), e202201739, database is CAplus and MEDLINE.

A series of bifunctional P,N ligands based on chiral spirocyclic and biaryl scaffolds were synthesized and applied in the gold(I)-catalyzed desym. lactonization of alkynylmalonic acids. A wide range of chiral lactones containing an α-position quaternary stereocenter were synthesized with high yields, excellent regioselectivity and enantioselectivity under mild reaction conditions. The synthetic utilities of the current reaction were demonstrated by gram-scale synthesis and transformations of chiral lactones. The origin of enantioselectivity and the role of the alc. additive were elucidated via control experiments and DFT calculations

Angewandte Chemie, International Edition published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Category: benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Yang, Yongyu published the artcileChemical constituents of Morus alba L. and their inhibitory effect on 3T3-L1 preadipocyte proliferation and differentiation, Quality Control of 56317-21-6, the publication is Fitoterapia (2014), 222-227, database is CAplus and MEDLINE.

Mulberry leaf, an important traditional Chinese medicine, possesses many biol. activities, including effects of anti-obesity. However, which constituents of mulberry leaf are responsible for its anti-adipogenic action is unclear. This study primarily investigated the chem. constituents from mulberry leaf and their bioactivity on the proliferation and differentiation of 3T3-L1 preadipocytes. A new flavane derivative, (2S)-4′-hydroxy-7-methoxy-8-prenylflavan (1), together with twelve known compounds including three flavanes (2-4), three chalcones (5-7), two flavones (8-9), two benzofurans (10-11) and two coumarin (12-13) was isolated from mulberry leaf. The structure of the new compound was elucidated by various spectroscopic methods including UV, HR-ESI-MS, ¹H and ¹³C NMR and CD. The results of activity screening showed that compound 2, 6 and 7 inhibited the proliferation and differentiation of 3T3-L1 preadipocytes.

Fitoterapia published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C7H13BrSi, Quality Control of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Tan, Yong-Xia published the artcileBioactive 2-arylbenzofuran derivatives from Morus wittiorum, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Fitoterapia (2010), 81(7), 742-746, database is CAplus and MEDLINE.

Investigation of an ethanol extract from the stem bark of Morus wittiorum led to the isolation of five new 2-arylbenzofuran derivatives that were named wittifuran S, wittifuran T, wittifuran V, wittifuran W and wittifuran X (1-5). Structures were determined on the basis of spectroscopic anal. Two new wittifurans and five previously isolated compounds were assayed for antioxidant and anti-inflammatory activity.

Fitoterapia published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C20H12N2O2, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Wang, Lei published the artcileThree new compounds from Morus nigra L., HPLC of Formula: 56317-21-6, the publication is Journal of Asian Natural Products Research (2010), 12(6), 431-437, database is CAplus and MEDLINE.

A new 2-arylbenzofuran derivative, mornigrol D (1), along with two new flavones, mornigrol G (2) and mornigrol H (3), and six known compounds, norartocarpetin (4), dihydrokaempferol (5), albanin A (6), albanin E (7), moracin M (8), and albafuran C (9), were isolated from the barks of Morus nigra. Their structures were elucidated by spectroscopic anal. Compounds 1 and 9 showed antioxidative activities in vitro with inhibition ratios of 98 and 99% at the concentration of 10^-4 mol/l, and of 74 and 75% at the concentration of 10^-5 mol/l. In addition, compounds 1 and 4 showed potent anti-inflammatory activities (inhibition of release of β-glucuronidase from rat polymorphonuclear leukocytes induced by platelet activating factor) with inhibitory ratios of 65.9% (P < 0.01) and 67.7% (P < 0.01) at a concentration of 10^-5 mol/l.

Journal of Asian Natural Products Research published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C25H47NO8, HPLC of Formula: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Blevins, David W. published the artcileIododemetallation of potassium organotrifluoroborates and tributylarylstannanes using sodium iodide/iron(III) chloride, Product Details of C8H5IO, the publication is Tetrahedron Letters (2015), 56(23), 3130-3132, database is CAplus.

A combinative iron(III) chloride/sodium iodide system was found to be very efficient for the iododemetallation of both organotrifluoroborates and tributyl(aryl)stannanes. A variety of functional groups tolerate the mild reaction conditions.

Tetrahedron Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Product Details of C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Wu, Chunlin published the artcileCobalt-Catalyzed Intramolecular Reactions between a Vinylcyclopropane and an Alkyne: Switchable [5+2] Cycloaddition and Homo-Ene Pathways, Computed Properties of 69626-75-1, the publication is Angewandte Chemie, International Edition (2018), 57(22), 6558-6562, database is CAplus and MEDLINE.

Cobalt-diphosphine catalysts have been found to promote intramol. reactions between a vinylcyclopropane and an alkyne to selectively afford either the [5+2] cycloaddition product or the homo-ene reaction product under solvent control. The former product is exclusively formed in noncoordinating 1,2-dichloroethane, whereas the latter is dominant in coordinating solvents, such as acetonitrile and dimethylacetamide. Furthermore, a highly enantioselective variant of the homo-ene reaction afforded chiral THF, pyrrolidine, and cyclopentane derivatives bearing 1,3-diene and alkylidene substituents. Thus, e.g., cycloaddition of I afforded II (85%) in presence of CoI₂, dppp, Zn and ZnI₂ in DCE, whereas the same catalytic system exclusively afforded homo-ene product III (86%) in NMP.

Angewandte Chemie, International Edition published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C15H21BO2, Computed Properties of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Hou, Zhen-Lin published the artcilePeptide modification via N-terminal-residue-directed γ-C(sp³)-H arylation, COA of Formula: C8H5IO, the publication is Organic Letters (2020), 22(21), 8692-8696, database is CAplus and MEDLINE.

Post-assembly modification of peptides via C(sp³)-H functionalization provides an efficient way to prepare functionalized peptides for biol. study and pharmaceutical development. In this work, we developed a new method for γ-C(sp³)-H functionalization of aliphatic side chains of N-terminus-unprotected peptides. With the N-terminal residues as directing groups, a wide range of di-, tri-, tetra-, and pentapeptides underwent C-H arylation of the residues (Val, Ile, Tle) at the +2 position from the N-terminus.

Organic Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, COA of Formula: C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Celaje, Jeff A. published the artcileChemistry of trans-Resveratrol with Singlet Oxygen: [2 + 2] Addition, [4 + 2] Addition, and Formation of the Phytoalexin Moracin M, HPLC of Formula: 56317-21-6, the publication is Organic Letters (2011), 13(18), 4846-4849, database is CAplus and MEDLINE.

Resveratrol reacts with singlet oxygen by two major pathways: A [2 + 2] cycloaddition forming a transient dioxetane that cleaves into the corresponding aldehydes and a [4 + 2] cycloaddition forming an endoperoxide that, upon heating, undergoes a rearrangement to moracin M. The rate constant by which singlet oxygen is removed by resveratrol (k_T) was determined by time-resolved IR luminescence spectroscopy to be 1.5 × 10⁶ M^-1 sec^-1 in CD₃OD, smaller than previously reported values. Chem. reaction accounts for ca. 25% of k_T.

Organic Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, HPLC of Formula: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Xu, Tianlong published the artcileCu-Catalyzed Consecutive Hydroxylation and Aerobic Oxidative Cycloetherification under Microwave Conditions: Entry to 2-Arylbenzofuran-3-carboxylic Acids, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Journal of Organic Chemistry (2015), 80(9), 4313-4324, database is CAplus and MEDLINE.

A convenient one-pot synthesis of 2-arylbenzofuran-3-carboxylic acids from (E)-2-(2-bromophenyl)-3-phenylacrylic acids via Cu-catalyzed consecutive hydroxylation and aerobic oxidative cycloetherification under microwave conditions has been developed. This protocol employed the reagent combination of Cu(OAc)₂, 1,10-phen, and KOH in DMSO/H₂O (1:1), all of which are cost-effective, readily available, and easily removable from the reaction mixture Utilizing this synthetic protocol, various 2-arylbenzofuran-3-carboxylic acids as well as the natural product moracin M have been synthesized in satisfactory yields under mild conditions.

Journal of Organic Chemistry published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C10H7NO3, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem