Tag: 426.53

Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents was written by Cao, Chun-Yan;Shen, Ying-Ying;Wang, Jian-Dong;Li, Li;Liang, Gao-Lin. And the article was included in Scientific Reports in 2013.Electric Literature of C19H30N4O5S This article mentions the following:

Herein we developed a new “smart” Gd-based MR contrast agent (i.e., 1) which is susceptive to furin, a protease overexpressed in tumor. Under the action of furin, 1 condenses to form dimers (1-Ds) and the latter self-assemble into gadolinium nanparticles (Gd-NPs). Relaxivity of 1-D is more than 2 folds of those of 1 and magnevist at 1.5 T, and 1.4 folds of that of 1 at 3 T. Intracellular condensation of 1 in furin-overexpressed MDA-MB-468 cells was proven with direct two-photon laser microscopy (TPLM) fluorescence imaging of the cells incubated with the europium analog of 1 (i.e., 2). Intracellular Gd-NPs of 1 were uncovered and characterized for the first time. MRI of MDA-MB-468 tumors showed that 1 has enhanced MR contrast within the tumors than that of its scrambled control 1-Scr. In the experiment, the researchers used many compounds, for example, H-Arg(Pbf)-OH (cas: 200115-86-2Electric Literature of C19H30N4O5S).

H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Electric Literature of C19H30N4O5S

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Gadolinium-based contrast agents targeted to amyloid aggregates for the early diagnosis of Alzheimer’s disease by MRI was written by Bort, Guillaume;Catoen, Sarah;Borderies, Helene;Kebsi, Adel;Ballet, Sebastien;Louin, Gaelle;Port, Marc;Ferroud, Clotilde. And the article was included in European Journal of Medicinal Chemistry in 2014.SDS of cas: 200115-86-2 This article mentions the following:

While important efforts were made in the development of positron emission tomog. (PET) tracers for the in vivo mol. diagnosis of Alzheimer’s disease, very few investigations to develop magnetic resonance imaging (MRI) probes were performed. Here, a new generation of Gd(III)-based contrast agents (CAs) is proposed to detect the amyloid β-protein (Aβ) aggregates by MRI, one of the earliest biol. hallmarks of the pathol. A building block strategy was used to synthesize a library of 16 CAs to investigate structure-activity relationships (SARs) on physicochem. properties and binding affinity for the Aβ aggregates. Three types of blocks were used to modulate the CA structures: (i) the Gd(III) chelates (Gd(III)-DOTA and Gd(III)-PCTA), (ii) the biovectors (2-arylbenzothiazole, 2-arylbenzoxazole and stilbene derivatives) and (iii) the linkers (neutrals, positives and negatives with several lengths). These investigations revealed unexpected SARs and a difficulty of these probes to cross the blood-brain barrier (BBB). General insights for the development of Gd(III)-based CAs to detect the Aβ aggregates are described. In the experiment, the researchers used many compounds, for example, H-Arg(Pbf)-OH (cas: 200115-86-2SDS of cas: 200115-86-2).

H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.SDS of cas: 200115-86-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reprogramming Urokinase into an Antibody-Recruiting Anticancer Agent was written by Jakobsche, Charles E.;McEnaney, Patrick J.;Zhang, Andrew X.;Spiegel, David A.. And the article was included in ACS Chemical Biology in 2012.HPLC of Formula: 200115-86-2 This article mentions the following:

Synthetic compounds for controlling or creating human immunity have the potential to revolutionize disease treatment. Motivated by challenges in this arena, we report herein a strategy to target metastatic cancer cells for immune-mediated destruction by targeting the urokinase-type plasminogen activator receptor (uPAR). Urokinase-type plasminogen activator (uPA) and uPAR are overexpressed on the surfaces of a wide range of invasive cancer cells and are believed to contribute substantially to the migratory propensities of these cells. The key component of our approach is an antibody-recruiting mol. that targets the urokinase receptor (ARM-U). This bifunctional construct is formed by selectively, covalently attaching an antibody-binding small mol. to the active site of the urokinase enzyme. We demonstrate that ARM-U is capable of directing antibodies to the surfaces of target cancer cells and mediating both antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotoxicity (ADCC) against multiple human cancer cell lines. We believe that the reported strategy has the potential to inform novel treatment options for a variety of deadly, invasive cancers. In the experiment, the researchers used many compounds, for example, H-Arg(Pbf)-OH (cas: 200115-86-2HPLC of Formula: 200115-86-2).

H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.HPLC of Formula: 200115-86-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents was written by Cao, Chun-Yan;Shen, Ying-Ying;Wang, Jian-Dong;Li, Li;Liang, Gao-Lin. And the article was included in Scientific Reports in 2013.Electric Literature of C19H30N4O5S This article mentions the following:

Herein we developed a new “smart” Gd-based MR contrast agent (i.e., 1) which is susceptive to furin, a protease overexpressed in tumor. Under the action of furin, 1 condenses to form dimers (1-Ds) and the latter self-assemble into gadolinium nanparticles (Gd-NPs). Relaxivity of 1-D is more than 2 folds of those of 1 and magnevist at 1.5 T, and 1.4 folds of that of 1 at 3 T. Intracellular condensation of 1 in furin-overexpressed MDA-MB-468 cells was proven with direct two-photon laser microscopy (TPLM) fluorescence imaging of the cells incubated with the europium analog of 1 (i.e., 2). Intracellular Gd-NPs of 1 were uncovered and characterized for the first time. MRI of MDA-MB-468 tumors showed that 1 has enhanced MR contrast within the tumors than that of its scrambled control 1-Scr. In the experiment, the researchers used many compounds, for example, H-Arg(Pbf)-OH (cas: 200115-86-2Electric Literature of C19H30N4O5S).

H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Electric Literature of C19H30N4O5S

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem