With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-11-2,5-Bromobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.
Example 9b: 5-cyanobenzofuran-2-carboxylic acid5-Bromobenzofuran-2-carboxylic acid (482 mg, 2 mmol) and CuCN (213 mg, 2.4 mmol) were suspended in NMP (lOmL). The reaction was irradiated using a microwave at 200C for 20 minutes. The reaction mixture was dissolved in ethyl acetate and washed with water and brine. The organic layer was evaporated under vacuum. The product was purified using Varian HPLC (10%-95% ACN in H20: 25 minute gradient). The combined fractions were concentrated under vacuum to give the title compound (115 mg).
10242-11-2 5-Bromobenzofuran-2-carboxylic acid 735247, abenzofuran compound, is more and more widely used in various.
Reference£º
Patent; SENOMYX, INC.; TACHDJIAN, Catherine; LI, Xiaodong; KARANEWSKY, Donald S.; FOTSING, Joseph; PATRON, Andrew; DARMOHUSODO, Vincent; SELCHAU, Victor; CHING, Brett; WO2011/159781; (2011); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem