With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21535-97-7,3-Methylbenzofuran,as a common compound, the synthetic route is as follows.
Compound E-3 (16 g, 121 mmol) was dissolved in 1,4-dioxane solution (100 mL), and then add selenium dioxide (17.5g, 157mmol), then, the mixture was stirred and refluxed for 16 hours. The reaction was cooled to room temperature, and the mixture was diluted with ethyl acetate /hexane (2:1, 100 mL). After stirring for 10 min, the insoluble material was removed by filtration and washed with ethyl acetate. The combined filtrates were concentrated under reduced pressure and purified by silica gel column chromatographyThe product was obtained as a yellow solid 7.3 g, yield 41%, 21535-97-7
The synthetic route of 21535-97-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sichuan University; Li Guobo; Wu Yong; Wang Yaoling; Liu Sha; Yu Zhujun; Yan Yuhang; Huang Mengyi; (39 pag.)CN110156820; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem