Some scientific research about 2,5-Dimethylfuran-3(2H)-one

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 14400-67-0. Quality Control of 2,5-Dimethylfuran-3(2H)-one.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, belongs to benzofurans compound. In a document, author is Khan, Samra, introduce the new discover, Quality Control of 2,5-Dimethylfuran-3(2H)-one.

Probing 2-acetylbenzofuran hydrazones and their metal complexes as alpha-glucosidase inhibitors

Inhibition of alpha-glucosidase is one of the important approaches in designing antidiabetic drugs for its role in decrease of the carbohydrates digestion to avoid post-prandial increase in blood sugar levels in diabetic patients. In the present study we designed a novel series of 2-acetylbenzofuran hydrazones (L1-L7) and their metal (II) complexes Cu (II), Co (II), Zn (II) and Mn (II) (8-29) and screened for inhibitory activity against the yeast alpha-glucosidase. The synthesis of hydrazones incorporated the use of I-2 as a catalyst which resulted in excellent yield of 94%. The ligand L3, showed good activity (IC50 = 47.51 +/- 0.86 mu M) while its metal complex (10) showed potent activity (IC50 = 1.15 +/- 0.001 mu M) compared to reference acarbose IC50 = 378.25 +/- 0.12 mu M. Similarly, the Cu (II) complexes with ligands L5 and L6 showed excellent alpha-glucosidase inhibition (IC50 = 0.15 +/- 0.003 12 and 0.21 +/- 0.002 mu M for 13, respectively) whereas, the metal complexes of Co (II), Mn (II), and Zn (II) showed moderate to poor inhibitory activities against alpha-glucosidase. The The findings are supported by the ligands and enzyme interactions through molecular docking studies. In conclusion, it is indicated that metal complexes of 2-acetylbenzofuran hydrazones have good potential for research leading to antidiabetic therapies.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 14400-67-0. Quality Control of 2,5-Dimethylfuran-3(2H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem