Related Products of 64175-51-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 64175-51-5, 2-(Benzofuran-3-yl)acetic acid, introducing its new discovery.
Design and synthesis of tailored human caseinolytic protease P inhibitors
Human caseinolytic protease P (hClpP) is important for degradation of misfolded proteins in the mitochondrial unfolded protein response. We here introduce tailored hClpP inhibitors that utilize a steric discrimination in their core naphthofuran scaffold to selectively address the human enzyme. This novel inhibitor generation exhibited superior activity compared to previously introduced beta-lactones, optimized for bacterial ClpP. Further insights into the bioactivity and binding to cellular targets were obtained via chemical proteomics as well as proliferation- and migration studies in cancer cells.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 64175-51-5. In my other articles, you can also check out more blogs about 64175-51-5
Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H2668O – PubChem