54109-03-4, Name is 5-Chloroisobenzofuran-1(3H)-one, belongs to benzofurans compound, is a common compound. COA of Formula: C8H5ClO2In an article, once mentioned the new application about 54109-03-4.
The direct carbonylation of C-H bonds in the benzene ring of N-phenylpyrazoles via catalysis by ruthenium or rhodium complexes is described. The reaction of N-phenylpyrazoles with carbon monoxide and ethylene in the presence of Ru3(CO)12 or Rh4(CO)12 resulted in the site-selective carbonylation of the ortho C-H bonds in the benzene ring to give the corresponding ethyl ketones. A variety of functional groups on the benzene ring can be tolerated. N-Phenylpyrazoles have higher reactivities than would be expected, based on the pKa values of the conjugate acid of pyrazole. The choice of solvent for this reaction is significant, and N, N-dimethylacetamide (DMA) gives the best result.
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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2609O – PubChem