23145-07-5, 5-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(i)3-Hydroxy-4,6-dichloro-1,3-dihydro-3-(benzofuran-5-yl)indole-2-one2.25 g of magnesium for a Grignard reaction in 15 ml of anhydrous THF are placed in a round-bottomed flask equipped with a mechanical stirrer, and under a stream of nitrogen.A mixture of 13.6 g of 5-bromobenzofuran in 35 ml of anhydrous THF is then added.The mixture is stirred for one hour, followed by addition of a solution of 5 g of 4,6-dichloro-1H-indole-2,3-dione in 50 ml of anhydrous THF.The mixture is stirred at room temperature for 4 hours 30 minutes.Water is added and the resulting mixture is extracted with ethyl acetate.The organic phase is separated out, dried over Na2SO4, filtered and evaporated under vacuum.The residue is taken up in ethyl acetate and washed with 1N sodium hydroxide solution.The organic phase is dried over Na2SO4, filtered and evaporated under vacuum.The solid is taken up in ethyl ether and filtered off. 4.2 g of expected product are obtained., 23145-07-5
23145-07-5 5-Bromobenzofuran 90015, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; SANOFI; US2011/312972; (2011); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem