With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-10-1,5-Chlorobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.
10242-10-1, LiAlH4 (0.12 g, 3.1 mmol) was weighed into a flask, THF (15.0 mL) was added,After stirring at 0 C for 10 minutes, 1-g (0.61 g, 3.1 mmol) was added, and the mixture was stirred at 0 C for 20 minutes.The reaction was quenched by adding H2O (5 mL) dropwise, diluted with ethyl acetate, filtered, washed with ethyl acetate, concentrated by rotary distillation and purified by silica gel column chromatography to give the product of formula 2-g.
10242-10-1 5-Chlorobenzofuran-2-carboxylic acid 937838, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; Chinese Academy Of Sciences Chemical Institute; Shi Yian; Li Zequan; Tian Hua; (29 pag.)CN106588952; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem