Genotoxicity testings: phage T7 inactivation test of various furan and arenofuran derivatives was written by Ronto, G.;Fekete, A.;Grof, P.;Bilger, C.;Buisson, J. P.;Tromelin, A.;Demerseman, P.. And the article was included in Mutagenesis in 1989.Formula: C8H5NO3 This article mentions the following:
The genotoxic activities of 28 furan and arenofuran derivatives were tested by the phage T7-inactivation test. The genotoxic activity of the compounds was characterized quant. All the compounds studied have pronounced genotoxic activities in the system. Empirical rules relating structure to genotoxic activity were found. Data obtained with the system were compared with the results of other biol. systems (Salmonella assay, SOS Chromotest, CHO/HGPRT, gene amplification) in the case of some compounds included as references In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Formula: C8H5NO3).
2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C8H5NO3
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem