Properties and Exciting Facts About 497-23-4

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 497-23-4. Name: Furan-2(5H)-one.

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Name: Furan-2(5H)-one497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a article, author is Watanabe, Hiroyuki, introduce new discover of the category.

Synthesis and evaluation of novel two-photon fluorescence probes for in vivo imaging of amylin aggregates in the pancreas

The deposition of islet amyloid consisting of amylin aggregates is one of the hallmarks of type 2 diabetes mellitus (T2DM). Therefore, the amylin aggregate is regarded as an attractive target for diagnosis, treatment and elucidation of the pathogenic mechanism of T2DM. However, no fluorescence probe for in vivo imaging of amylin aggregates has been reported. In this study, we evaluated four fluorescent probes (DANIRs) including two novel compounds (DANIR-OH 2b and DANIR-OH 2c) for two-photon fluorescence imaging of amylin aggregates in the pancreas. All DANIFts showed binding affinity for amylin aggregates and clearly stained amylin aggregates in pancreatic sections of the islet amylin model mice and T2DM patients in in viwo. In an ex vivo fluorescence staining study, these probes also bound to amylin aggregates in the pancreas of the islet amylin model mice. Furthermore, in an in vivo two-photon fluorescence imaging study, we clearly imaged the amylin aggregates after injecting DANIFts via the tail vein of the islet amyloid model mice. The results suggest that DANIRs may be useful for two-photon fluorescence imaging of amylin aggregates in the living mouse pancreas.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 497-23-4. Name: Furan-2(5H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem