4412-91-3, Name is 3-Furanmethanol, molecular formula is C5H6O2, SDS of cas: 4412-91-3, belongs to benzofurans compound, is a common compound. In a patnet, author is Watanabe, Hiroyuki, once mentioned the new application about 4412-91-3.
Development of Novel PET Imaging Probes for Detection of Amylin Aggregates in the Pancreas
m The deposition of islet amyloid is associated with beta-cell mass dysfunction in type 2 diabetes mellitus (T2DM). Since the amylin aggregate is the main component of islet amyloid, in vivo imaging of amylin may be useful for diagnosis and elucidation of the pathogenic mechanism of T2DM. In the present study, we newly designed, synthesized, and evaluated two F-18 labeled compounds ([F-18]DANIR-F 2b and [F-18]DANIR-F 2c) as positron emission tomography (PET) probes targeting amylin aggregates. In an in vitro binding study, DANIR-F 2b and DANIR-F 2c showed binding affinity for amylin aggregates (K-i = 160 and 29 nM, respectively). In addition, [F-18]DANIR-F 2b and [F-18]DANIR-F 2c clearly labeled islet amyloids in in vitro autoradiography of T2DM pancreatic sections. In the biodistribution study using normal mice, [F-18]DANIR-F 2b and [F-18]DANIR- F 2c displayed favorable pharamacokinetics in the pancreas and some organs located near the pancreas. Furthermore, in an ex vivo autoradiographic study, [F-18]DANIR-F 2c also bound to amylin aggregates in the pancreas of the amylin transplanted mice. The results of this study suggest that [F-18]DANIR-F 2c shows fundamental properties as a PET imaging probe targeting amylin aggregates in the T2DM pancreas.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 4412-91-3 help many people in the next few years. SDS of cas: 4412-91-3.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem