Molecular nanoinformatics approach assessing the biocompatibility of biogenic silver nanoparticles with channelized intrinsic steatosis and apoptosis was written by Panda, Pritam Kumar;Kumari, Puja;Patel, Paritosh;Samal, Shailesh Kumar;Mishra, Suman;Tambuwala, Murtaza M.;Dutt, Ateet;Hilscherova, Klara;Mishra, Yogendra Kumar;Varma, Rajender S.;Suar, Mrutyunjay;Ahuja, Rajeev;Verma, Suresh K.. And the article was included in Green Chemistry in 2022.Related Products of 496-16-2 This article mentions the following:
The developmental rapidity of nanotechnol. poses higher risks of exposure to humans and the environment through manufactured nanomaterials. The multitude of biol. interfaces, such as DNA, proteins, membranes, and cell organelles, which come in contact with nanoparticles, is influenced by colloidal and dynamic forces. Consequently, the ensued nano-bio interface depends on dynamic forces, encompasses many cellular absorption mechanisms along with various biocatalytic activities, and biocompatibility that needs to be investigated in detail. Addressing the issue, the study offers a novel green synthesis strategy for antibacterial AgNPs with higher biocompatibility and elucidates the mechanistic in vivo biocompatibility of silver nanoparticles (AgNPs) at the cellular and mol. levels. The anal. ascertained the biosynthesis of G-AgNPs with the size of 25 ± 10 nm and zeta potential of -29.2 ± 3.0 mV exhibiting LC50 of 47.2 μg mL-1 in embryonic zebrafish. It revealed the mechanism as a consequence of abnormal physiol. metabolism in oxidative stress and neutral lipid metabolism due to dose-dependent interaction with proteins such as he1a, sod1, PEX protein family, and tp53 involving amino acids such as arginine, glutamine and leucine leading to improper apoptosis. The research gave a detailed insight into the role of diverse AgNPs-protein interactions with a unique combinatorial approach from first-principles d. functional theory and in silico analyses, thus paving a new pathway to comprehending their intrinsic properties and usage. In the experiment, the researchers used many compounds, for example, 2,3-Dihydrobenzo[b]furan (cas: 496-16-2Related Products of 496-16-2).
2,3-Dihydrobenzo[b]furan (cas: 496-16-2) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Related Products of 496-16-2
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem