Synthesis of protein kinase Cδ C1b domain by native chemical ligation methodology and characterization of its folding and ligand binding was written by Ohashi, Nami;Nomura, Wataru;Kato, Mai;Narumi, Tetsuo;Lewin, Nancy E.;Blumberg, Peter M.;Tamamura, Hirokazu. And the article was included in Journal of Peptide Science in 2009.Computed Properties of C19H30N4O5S This article mentions the following:
The C1b domain of protein kinase Cδ (PKCδ), a potent receptor for ligands such as diacylglycerol and phorbol esters, was synthesized by utilizing native chem. ligation. With this synthetic strategy, the domain was efficiently constructed and shown to have high affinity ligand binding and correct folding. The C1b domain has been utilized for the development of novel ligands for the control of phosphorylation by PKC family members. This strategy will pave the way for the efficient construction of C1b domains modified with fluorescent dyes, biotin, etc. In the experiment, the researchers used many compounds, for example, H-Arg(Pbf)-OH (cas: 200115-86-2Computed Properties of C19H30N4O5S).
H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Computed Properties of C19H30N4O5S
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem