4412-91-3, Name is 3-Furanmethanol, molecular formula is C5H6O2, belongs to benzofurans compound, is a common compound. In a patnet, author is Shrestha, Srijan, once mentioned the new application about 4412-91-3, Category: benzofurans.
Insight into the PTP1B Inhibitory Activity of Arylbenzofurans: An In Vitro and In Silico Study
Protein tyrosine phosphatase 1B (PTP1B) plays a specific role as a negative regulator of insulin signaling pathways and is a validated therapeutic target for Type 2 diabetes. Previously, arylbenzofurans were reported to have inhibitory activity against PTP1B. However, detailed investigation regarding their structure activity relationship (SAR) has not been elucidated. The main aim of this work was to investigate the PTP1B inhibitory activity of 2-arylbenzofuran analogs (sanggenofuran A (SA), mulberrofuran D2 (MD2), mulberrofuran D (MD), morusalfuran B (MB), mulberrofuran H (MH)) isolated from the root bark of Morus alba. All compounds demonstrated potent inhibitory activity with IC50 values ranging from 3.11 to 53.47 mu M. Among the tested compounds, MD2 showed the strongest activity (IC50, 3.11 mu M), followed by MD and MB, while SA and MH demonstrated the lowest activity. Lineweaver-Burk and Dixon plots were used for the determination of inhibition type whereas ligand and receptor interactions were investigated in modeled complexes via molecular docking. Our study clearly supports 2-arylbenzofuran analogs as a promising class of PTP1B inhibitors and illustrates the key positions responsible for the inhibitory activity, their correlation, the effect of prenyl/geranyl groups, and the influence of resorcinol scaffold, which can be further explored in-depth to develop therapeutic agents against T2DM.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 4412-91-3. The above is the message from the blog manager. Category: benzofurans.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem