New explortion of Benzo[b]furan-2-carboxaldehyde

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, name: Benzo[b]furan-2-carboxaldehyde, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 4265-16-1

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: Benzo[b]furan-2-carboxaldehyde, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 4265-16-1, Name is Benzo[b]furan-2-carboxaldehyde, molecular formula is C9H6O2

Oxidation of furan-2-carboximidamides 8 by (dicarboxyiodo)benzenes gives N1-acyl-N1-(2-furyl)ureas 9 via rearrangement to a carbodiimide. Thermolysis of eleven ureas 9 gave the corresponding 2-acylaminofurans 10, which cannot be made from the free amines owing to their high instability. When oxidation of the corresponding benzo[b]furan derivatives 12 was investigated a new type of product was isolated, in addition to the expected ureas 14, and these were shown to be benzo[4,5]furo[2,3-d]pyrimidine derivatives 15. The mechanism of formation of these products must involve reaction of the carbodiimide intermediate with the amidine precursor and cyclisation of the resulting guanidine derivatives 19. The corresponding tetraphenylguanidine 21 was prepared and underwent thermal cyclisation but the quinazoline derivative formed 23 was shown to occur via an alternative cyclisation mechanism. The structures of cyclisation products 15 and 23 were confirmed by X-ray crystallography. N-(2-Furyl)acetamide 10a readily undergoes cycloaddition reactions with electron-deficient alkynes to give phenols after spontaneous ring opening. Observed regioselectivity is in agreement with the results of AM1 molecular orbital calculations. Reaction of the amide 10a with Lawesson’s reagent gave the thioamide 26.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, name: Benzo[b]furan-2-carboxaldehyde, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 4265-16-1

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H749O – PubChem