I found the field of Chemistry very interesting. Saw the article Reversal of diastereoselectivity in palladium-arene interaction directed hydrogenative desymmetrization of 1,3-diketones published in 2020. Product Details of 87-41-2, Reprint Addresses Fan, HJ; Zhou, YG (corresponding author), Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one
For the metal-catalyzed asymmetric hydrogenation of alpha-substituted ketones, cis reductive products are generally obtained due to steric hindrance of substituents. Herein, an unprecedented trans reductive products were observed in palladium-catalyzed hydrogenative desymmetrization of cyclic and acyclic 1,3-diketones, providing the chiral trans beta-hydroxy ketones with two adjacent stereocenters including one alpha-tertiary or quaternary stereocenter with high enantioselectivity and diastereoselectivity. Mechanistic studies and DFT calculations suggested that the rarely observed diastereoselectivity reversal is ascribed to the charge-charge interaction between the palladium and aromatic ring of the substrate, which could not only result in the reversal of the diastereoselectivity, but also improve the reactivity.
Welcome to talk about 87-41-2, If you have any questions, you can contact Yu, CB; Wang, HD; Song, B; Shen, HQ; Fan, HJ; Zhou, YG or send Email.. Product Details of 87-41-2
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem