Application of 496-41-3, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 496-41-3, Name is Benzofuran-2-carboxylic acid, molecular formula is C9H6O3. In a Article£¬once mentioned of 496-41-3
Non-carboxylic antiinflammatory compounds. III. N-(4,6-Dimethylpyridin-2-yl)arylcarboxamides and arylthiocarboxamides acting as brain edema inhibitors
Pharmacomodulation of the non-carboxylic NSAID N-(4,6-dimethylpyridin-2-yl)benzamide 1 led to the synthesis of structurally related furan, thiophene and pyrrole carboxamides 3-14.The derivatives benzenethiocarboxamides 15-18 and hetroarylthiocarboxamides 19-22 were also prepared by oxygen/sulfur exhange; this reaction was more efficiently carried out P4S10 than by Lawesson’s reagent.The 20 synthesized compounds were evaluated against peripheral edema by a foot-pad carrageenin-induced edema test.Amides 3-5,8,9,11,12 and 14 were most active, exhibiting > 90percent inhibitionafter oral administration of 0.8 mmol*kg-1.Two amides 3 and 5 were selected for evaluation of their inhibitory in PLA2-induced brain edema and were found to be more potent than dexamethasone IP administration. – Keywords: 2-amino-4,6-dimethylpyridine; heteroarylcarboxamide; (hetero)thiocarboxamide; non-carboxylic NSAID; brain edema inhibitor
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 496-41-3. In my other articles, you can also check out more blogs about 496-41-3
Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H1943O – PubChem