Application of 497-23-4, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a article, author is Noviany, Noviany, introduce new discover of the category.
Structural revision of sesbagrandiflorains A and B, and synthesis and biological evaluation of 6-methoxy-2-arylbenzofuran derivatives
Sesbagrandiflorains A (1) and B (2), isolated from the stem bark of the Indonesian fabaceous plantSesbania grandiflora, were reported to be 6-methoxy-2-(2 ‘,3 ‘-dihydroxy-5 ‘-methoxyphenyl)-1-benzofuran-3-carbaldehyde and 6-hydroxy-2-(2 ‘,3 ‘-dihydroxy-5 ‘-methoxyphenyl)-1-benzofuran-3-carbaldehyde, respectively. However, based on reevaluation of their 1D and 2D NMR data, the chemical structures of 1 and 2 have been revised to 4-hydroxy-2-(4 ‘-hydroxy-2 ‘-methoxyphenyl)-6-methoxybenzofuran-3-carbaldehyde and 4-hydroxy-2-(4 ‘-hydroxy-2 ‘-hydroxyphenyl)-6-methoxybenzofuran-3-carbaldehyde, respectively. In addition, seven new derivatives of1have been synthesized from the natural product in good yields (65 – 93%). The chemical structures of the synthetic compounds-one diester (6), four ethers (7-10), one secondary amine (11), and one oxime (12)-were confirmed by MS and NMR analysis. Compound 6 exhibited moderate antibacterial activity against the plant pathogenRhodococcus fascianswith a MIC of 0.1 mg/mL. Compounds 8 and 12 demonstrated respectable cytotoxicity against A375 melanoma cancer cells line with the relative IC(50)values of 22.8 and 32.7 mu M, respectively.
Application of 497-23-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 497-23-4 is helpful to your research.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem