Extended knowledge of 1,3-Dihydroisobenzofuran-5-carbaldehyde

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Related Products of 89424-83-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.89424-83-9, Name is 1,3-Dihydroisobenzofuran-5-carbaldehyde, molecular formula is C9H8O2. In a Article,once mentioned of 89424-83-9

Series of 5-substituted-3,4-diphenylfuran-2-ones were stereoselectively prepared. Their potential anti-proliferative effects on prostate cancer and some of their cyclooxygenases (COXs) inhibitory activities were evaluated. Structure-activity relationship (SAR) data, acquired by substituent modification at the para-position and ortho-position of the C-3 phenyl ring and 5-substituted modification of the central furanone, showed that 3-(2-chloro-phenyl)-4-(4-methanesulfonyl-phenyl)-5-(1-methoxy-ethyl) -5H-furan-2-one (13p) was the most potent compound and could effectively reduce the proliferation of prostate cancer cells (PC3 cell IC50 = 20 muM; PC3 PCDNA cell IC50 = 5 muM; PC3 SKP2 cell IC50 = 5 muM; DU145 cell IC50 = 25 muM). The cell cycle analysis for 13p in DU145 indicated that 13p may induce G1 phase arrest.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1277O – PubChem