One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 496-41-3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 496-41-3, Name is Benzofuran-2-carboxylic acid, molecular formula is C9H6O3
Two new improved approaches to the synthesis of coumarin-based prodrugs
Our laboratory has recently reported the development of a coumarin- based, esterase-sensitive prodrug system for the preparation of prodrugs of amines, peptides, and peptidomimetics. Biological evaluations including animal studies have demonstrated the clinical potential of this prodrug system. However, the original synthetic method used required a long sequence of reactions with a relatively low overall yield. In this report, we describe two new approaches to the synthesis of these coumarin-based prodrugs. The first approach is a photochemical approach taking advantage of the photoisomerization of cinnamic acid and its derivatives. The second approach is through the catalytic hydrogenation of a triple bond for the generation of the cis double bond in the coumarinic acid moiety. Both approaches allow for the synthesis of these prodrugs in fewer steps with much improved overall yield.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Product Details of 496-41-3, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 496-41-3
Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H2048O – PubChem