35700-40-4, Name is 2,3-Dihydrobenzofuran-7-carboxylic acid, belongs to benzofurans compound, is a common compound. Safety of 2,3-Dihydrobenzofuran-7-carboxylic acidIn an article, once mentioned the new application about 35700-40-4.
New N-(1,2-diphenylethyl)piperazines 6 are disclosed as dual serotonin and noradrenaline reuptake inhibitors (SNRI) which may have potential in treating stress urinary incontinence (SUI). In this Letter, we present new data for SNRI PF-526014 (4) including performance in a canine in vivo model of SUI, cardiovascular assessment, pharmacokinetics in dog and determination of the primary routes of metabolism in vitro. Starting from 4, detailed structure activity relationships established that potent dual SNRIs could be achieved by appropriate substitution of the phenyl rings (6: R; R1) combined with a preferred stereochemistry. From this set of compounds, piperazine (-)-6a was identified as a potent and selective dual SNRI with improved metabolic stability and reduced ion channel activity when compared to 4. Based on this profile, (-)-6a was selected for further evaluation in a preclinical model of SUI.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 35700-40-4
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2198O – PubChem