Chemistry, like all the natural sciences, Product Details of 97148-39-5, begins with the direct observation of nature¡ª in this case, of matter.97148-39-5, Name is Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, SMILES is O=C([O-])/C(C1=CC=CO1)=NOC.[NH4+], belongs to benzofurans compound. In a document, author is Xie, Ting, introduce the new discover.
Selective Quadruple C(sp(3))-F Functionalization of Polyfluoroalkyl Ketones
The significance of organofluorine compounds has inspired the establishment of numerousmethods for the functionalization of rather inert C-F bonds. Despite advances achieved in the manipulation of C(sp(2))-F bonds by employing transitionmetal catalysts, such as Pd, Rh, Cu, Ni, Ru, and Ir, strategies that address the paucity of effective pathways for selective activation of multiple C(sp(3))-F bonds remained challenging. In this context, we present an unprecedented coupling-aromatization-cyclization reaction of polyfluorinated ketones with diverse Nand S-nucleophiles that forms regiodefined perfluoroalkylated naphtho[1,2-b] furan/benzofuran derivatives by harnessing Co-promoted distinctive quadruple C(sp(3))-F bonds cleavage relay. This chemistry involving controlled and successive selective defluorination at heteronuclear centers would greatly contribute to the preparation of drug-like heterocycles as well as the late-stage elaboration of bio-relevant compounds. Controlled experiments and DFT theoretical studies revealed that the combination of cheap cobalt salt with Cs2CO3 enable expeditious C-F functionalization.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 97148-39-5. Product Details of 97148-39-5.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem