With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.641-70-3,3-Nitrophthalic anhydride,as a common compound, the synthetic route is as follows.
641-70-3, Synthesis of 2-[4-(2-Chloroethoxy)benzoyl]-4-nitroindan-1,3-dione: To a suspension of 1-[4-(2-chloroethoxy)phenyl]-4,4,4-trifluorobutane-1,3-dione (59.3 g, 201 mmol) and 3-nitrophthalic anhydride (38.9 g, 201 mmol) at 0 C. in acetic anhydride (114 mL) was added triethylamine (41 g, 403 mmol). The mixture slowly turned deep red and became homogeneous. The reaction was allowed to warm to room temp. overnight. The reaction mixture was cooled to 0 C. and 2N HCl (600 mL) was added slowly. The mixture was vigorously stirred for 45 min. at room temp. until a brown granular ppt formed. The brown solid was collected by filtration, resuspended in H2O (250 mL) and stirred for 20 min. The brown solid was filtered and dried under vacuum. The crude reaction product was suspended in EtOH (500 mL) and then heated to boiling. The solution slowly turned deep red and the solid became bright yellow. The suspension was allowed to cool to room temp. The product was collected by filtration and dried under vacuum to give the triketone as a bright yellow solid (45 g, 60% yield).
641-70-3 3-Nitrophthalic anhydride 21631, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; Bockovich, Nicholas; Kluge, Arthur; Ram, Siya; Wang, Zhonghuo; Oalmann, Chris; Murthi, Krishna K.; US2003/162797; (2003); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem