Analyzing the synthesis route of 23145-07-5

23145-07-5, The synthetic route of 23145-07-5 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23145-07-5,5-Bromobenzofuran,as a common compound, the synthetic route is as follows.

5-bromobenzofuran (500 mg, 2.56 mmol) was dissolved in THF solution of isobutylzinc(H) bromide (0.5M, 15 mL, 7.40 mmol) in a microwave reaction tube. Pd(P1BUs)2 (65 mg, 0.128 mmol, 0.05 eqv.) was added to this solution. The mixture was purged with N2 gas for 3-5 min and heated at 100 0C for 30 min under microwave irradiation. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate, washed with IN HCl aqueous solution, brine, filtered through Celite. The filtrate was dried over Na2SO4 and concentrated. The residue was purified by silica gel column chromatography (ISCO system, 5percent EtOAc in hexanes) to give 0.331 g desired product (74percent yield): 1H NMR (400 MHz, CDCl3) delta 7.59 (s, IH), 7.35 (d, IH), 7.07 (d, IH), 6.70(s, IH), 2.59 (d, 2H)5 1.9 (m, IH), 0.9 (d, 6H).

23145-07-5, The synthetic route of 23145-07-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PREDIX PHARMACEUTICALS HOLDINGS, INC.; WO2007/61458; (2007); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem