496-41-3, An article , which mentions 496-41-3, molecular formula is C9H6O3. The compound – Benzofuran-2-carboxylic acid played an important role in people’s production and life.
Identification of benzothiophene amides as potent inhibitors of human nicotinamide phosphoribosyltransferase
Nicotinamide phosphoribosyltransferase (Nampt) is an attractive therapeutic target for cancer. A Nampt inhibitor with novel benzothiophene scaffold was discovered by high throughput screening. Herein the structure-activity relationship of the benzothiophene Nampt inhibitor was investigated. Several new inhibitors demonstrated potent activity in both biochemical and cell-based assays. In particular, compound 16b showed good Nampt inhibitory activity (IC50= 0.17 muM) and in vitro antitumor activity (IC50= 3.9 muM, HepG2 cancer cell line). Further investigation indicated that compound 16b could efficiently induce cancer cell apoptosis. Our findings provided a good starting point for the discovery of novel antitumor agents.
496-41-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 496-41-3
Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H1764O – PubChem