Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: benzofuran. Introducing a new discovery about 496-41-3, Name is Benzofuran-2-carboxylic acid
Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51
To further enhance the anti-Aspergillus efficacy of our previously discovered antifungal lead compound 1, a series of benzoheterocycle analogues were designed, synthesized and evaluated for their in vitro antifungal activity. The most promising compounds 13s and 14a exhibited excellent antifungal activity against C. albicans, C. neoformans, A. fumigatus and fluconazole-resistant C. albicans strains, that was superior or comparable to those of the reference drugs fluconazole and voriconazole. GC?MS analyses suggested that the novel compound 13s might have a similar mechanism to fluconazole by inhibiting fungal lanosterol 14alpha-demethylase (CYP51). Furthermore, compounds 13s and 14a exhibited low inhibition profiles for various human cytochrome P450 isoforms as well as excellent blood plasma stability.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: benzofuran, you can also check out more blogs about496-41-3
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Benzofuran – Wikipedia,
Benzofuran | C8H2047O – PubChem