496-41-3, Name is Benzofuran-2-carboxylic acid, belongs to benzofurans compound, is a common compound. SDS of cas: 496-41-3In an article, once mentioned the new application about 496-41-3.
A series of berberine-phenyl-benzoheterocyclic (26-29) and tacrine-phenyl-benzoheterocyclic hybrids (44-46) were synthesised and evaluated as multifunctional anti-Alzheimer’s disease agents. Compound 44b, tacrine linked with phenyl-benzothiazole by 3-carbon spacers, was the most potent AChE inhibitor with an IC50 value of 0.017 muM. This compound demonstrated similar Abeta aggregation inhibitory activity with cucurmin (51.8% vs 52.1% at 20 muM, respectively), indicating that this hybrid is an excellent multifunctional drug candidate for AD.
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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1825O – PubChem