Synthetic Route of 496-41-3, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 496-41-3, Name is Benzofuran-2-carboxylic acid,introducing its new discovery.
A series of N-(benzofuran-2-ylmethyl)-N?-benzylpiperazines bearing alkyl or fluoroalkyl aryl ethers were synthesized and evaluated at various central nervous system receptors. Examination of in vitro sigma1 {[3H](+)-pentazocine} and sigma2 ([3H]DTG) receptor binding profiles of piperazines 11-13 and 25-36 revealed several highly potent and sigma1 selective ligands, notably, N-(benzofuran-2- ylmethyl)-N?-(4?-methoxybenzyl)piperazine (13, Ki = 2.7 nM, sigma2/sigma1 = 38) and N-(benzofuran-2-ylmethyl)- N?-(4?-(2?-fluoroethoxy)benzyl)piperazine (30, Ki = 2.6 nM, sigma2/sigma1 = 187). Structural features for optimal sigma1 receptor affinity and selectivity over the sigma2 receptor were identified. On the basis of its favorable log D value, 13 was selected as a candidate for the development of a sigma1 receptor positron emission tomography radiotracer. [ 11C]13 showed high uptake in the brain and other sigma receptor-rich organs of a Papio hamadryas baboon. The in vivo evaluation of [11C]13 indicates that this radiotracer is a suitable candidate for imaging the sigma1 receptor in neurodegenerative processes.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 496-41-3, and how the biochemistry of the body works.Synthetic Route of 496-41-3
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1908O – PubChem