Preparation of benzo[b]furans having five-membered heterocycles at the 2-position and 2-(4-alkylcarbamoylbuta-1,3-dienyl)benzo[b]furans, and their cysteinyl leukotriene receptor (cysLT1, cysLT2) inhibitory activity was written by Akai, Yukiko;Tabuchi, Yukako;Ando, Kumiko;Ito, Azusa;Sakata, Yoko;Kawasaki, Ikuo;Ohishi, Takahiro;Yamashita, Masayuki;Ohta, Shunsaku;Nishide, Kiyoharu;Ohishi, Yoshitaka. And the article was included in Chemical & Pharmaceutical Bulletin in 2012.Formula: C10H7BrO2 This article mentions the following:
A series of benzo[b]furan derivatives having a 5-membered heterocyclic substituent at the 2-position were prepared from 2-(1-chloro-2-formylvinyl)benzo[b]furans and 2-[4-(alkylcarbamoyl)buta-1,3-dienyl]benzo[b]furans. The newly prepared 2-heterocyclic benzo[b]furans were evaluated for their cysteinyl leukotriene receptor (cysLT1, cysLT2) inhibitory activity. Several compounds showed moderate inhibition of Ca mobilization in HEK 293T-cysLT2 or CHO-cysLT1 cells. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Formula: C10H7BrO2).
1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Formula: C10H7BrO2
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem