With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59434-19-4,4-Aminophthalide,as a common compound, the synthetic route is as follows.
Example 139A(?)-6-Fluoro-4-((l -methyl- lH-imidazol-2-yl)methyleneamino)isobenzofuran- 1 (3H)-one[00798] A solution of 1 -methyl- lH-imidazole-2-carbaldehyde (659 mg, 6.0 mmol), 4-amino-6- fluoroisobenzofuran- 1 (3H)-one (1.0 g, 6.0 mmol), and anhydrous magnesium sulfate (7.2 g, 60.0 mmol) in acetonitrile (100 mL) was heated to reflux for 2 days. The solution was filtered and the solvents were removed in vacuum. The crude product was re-crystallized from isopropanol to afford the title compound (1.068 g, yield 68%) LC-MS (ESI) m/z: 260 (M+l)+. ?-NMR (400 MHz, DMSO-d6) delta (ppm): 4.04 (s, 3H), 5.49 (s, 2H), 7.24 (s, 1H), 7.54-7.58 (m, 2H), 7.73-7.76 (m, 1H), 8.70 (s, 1H).
As the paragraph descriping shows that 59434-19-4 is playing an increasingly important role.
Reference£º
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel; WO2011/130661; (2011); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem